منابع مشابه
M-CSF mediates TNF-induced inflammatory osteolysis.
TNF-alpha is the dominant cytokine in inflammatory osteolysis. Using mice whose BM stromal cells and osteoclast precursors are chimeric for the presence of TNF receptors, we found that both cell types mediated the cytokine's osteoclastogenic properties. The greater contribution was made, however, by stromal cells that express the osteoclastogenic cytokine M-CSF. TNF-alpha stimulated M-CSF gene ...
متن کاملA la recherche de la m-théorie perdue
We present the evidence for the existence of the topological string analogue of M-theory, which we call Z-theory. The corners of Z-theory moduli space correspond to the Donaldson-Thomas theory, Kodaira-Spencer theory, Gromov-Witten theory, and Donaldson-Witten theory. We discuss the relations of Z-theory with Hitchin’s gravities in six and seven dimensions, and make our own proposal, involving ...
متن کاملPW02-033 - Cytokine profile in CSF in CAPS patients
Introduction CAPS is a rare autoinflammatory syndrome caused by autosomal dominant mutations in the NLRP3/CIAS 1 gene on chromosome 1q44 encoding for the cryopyrin protein, an important component of the inflammasome, leading to excessive production of interleukin-1beta (IL-1ß). CAPS encompasses three different entities of variable clinical severity: familial cold auto-inflammatory syndrome (FCA...
متن کاملساخت cDNA جفت انسان و نشان دادن تجلی M-CSF در آن بافت
Macrophage colony stimulating factor (M-CSF) has previously been shown to affect the differentiation of cells of the mono-nuclear phagocytic line. More recent studies indicate that M-CSF may have a role in pregnancy. In the present study, the expression of M-CSF in the human placenta was demonstrated. Placental mRNA was isolated and used as template for synthesis of complementary DNA (cDNA). Th...
متن کاملCo-immunization with M-CSFR and mM-CSF DNA vaccines is better than M-CSFR-mM-CSF fusion DNA vaccine.
BACKGROUND AND OBJECTIVES DNA vaccine against macrophage colony-stimulating factor receptor (M-CSFR) has shown both protective and therapeutic effects. In this study, we explore the possibility of using DNA vaccines against both M-CSFR and membrane-bound macrophage colony-stimulating factor (mM-CSF) to achieve better effects. DESIGN AND METHODS Three plasmids were constructed by inserting eit...
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ژورنال
عنوان ژورنال: médecine/sciences
سال: 2009
ISSN: 0767-0974,1958-5381
DOI: 10.1051/medsci/2009258-9666